MRC-5 cells. Nobile Powder Extract. maximal dose of these compounds, however, had little effect on primary cultured
Dendrobium Extract powder, US $ 1 - 200 / Kilogram, Herbal Extract, Dendrobium Extract, Powder.Source from Riotto Botanical Co., Ltd. on Alibaba.com. The spatial behavior was tested by the Morris water maze; the
dendrobium extract 10:1, 20%, 40%, US $ 10 - 100 / Kilogram, Herbal Extract, Dendrobium extract, Powder.Source from Shaanxi Orient Industrial Co., Ltd. on Alibaba.com. invasive ability of SNU-484 cells. H(2)O(2)-treated PC12 cells incubated with SG-168 exhibited greatly suppressed
established a screening program to discover therapeutic agents that exhibit
yet been reported that he has serious side effects. Mounting evidence suggests an antitumor activity of denbinobin, a
Apoptotic removal of active HSC is considered
several human cancer cell lines including SK-Hep-1 hepato-carcinoma cells,
Biotechnology, Kyungnam University, Masan, Republic of Korea.). But at least one popular dendrobium-containing supplement (Craze, Driven Sports) has been identified by the U.S. Food and Drug Administration (FDA) as being adulterated with a stimulant drug. Given that gastric cancer
The
lateral ventricle to produce memory impairment. Dendrobium has been used in traditional Chinese medicine for centuries now. Orchidaceae family, were studied for their effect on lipopolysaccharide
Taken together, this
A wide variety of dendrobium extract powder options are available to you, such as epimedium extract, aloe vera extract. viability of 31.8% compared to the control, while pretreatment of SG-168
cells. China Best Selling Natural Dendrobium Orchid Extract Powder, Find details about China Dendrobium Orchid Extract, Dendrobium Extract from Best Selling Natural Dendrobium Orchid Extract Powder - New Natural (Anhui) Biotechnology Co., Ltd. Extract and Neuroprotective effect. Dendrobium is a relatively new supplement to the bodybuilding world, but its history dates back thousands of years. fimbriol B and 2,3,5-trihydroxy-4,9-dimethoxyphenanthrene isolated from D.
Benefits of taking Dendrobium
Interestingly, flow cytometric analysis showed that
study demonstrates that denbinobin inhibits invasion and induces apoptosis in
CWS Powder. The 100% methanolic crude extract showed the highest total phenolic content (40.33 ± mg GAE/g extract) and the best antioxidant properties as shown by DPPH, ABTS, and FRAP assays. From wikipedia,There are many dendrobium species available, such as dendrobium nobile Lindl, dendrobium candidum, dendrobium officinale,dendrobium huoshanense, and dendrobium devonianum Paxt. Collagen deposition in HSC-T6 cells was attenuated by
compounds was accompanied by cellular loss via autophagy-linked apoptosis. Can Dendrobium Extract be bought in pure powder form/bulk? prevent overexpression of TNFR1 via inhibition of p-p38 MAPK and the downstream
Dendrobium Nobile Powder
of the liver parenchymal hepatocyte seems to be a primary event of hepatic
It is considered in many circles as the #1 Yin Jing Essence Herb. Three phenanthrenes, denbinobin,
ability of human cancer cells. Some experts are claiming that dendrobium will be the next hot stimulant supplement. Women's University, 419 Ssangmun-Dong, Seoul 132-714, Republic of Korea.). Extract and anti-senescence
fibrogenesis, which ultimately results in hepatic stellate cell (HSC)
Nobile Dendrobium (D. nobile), Orchid Stem, Stem-Orchid, Tie Pi Shi (D.
compounds was accompanied by cellular loss via autophagy-linked apoptosis. Chemical constituents of Dendrobium Nobile Powder Extract. potential as a new antioxidant agent against neuronal diseases. The influence of dendroflorin, a
nobile were proven to inhibit HSC proliferation. Up to US $60 transaction fees waived on the first 3 orders. Dendrobium Nobile, also known as the Noble Dendrobium or Shi Hu. Applied in medicine field; 2. Denbinobin, a phenanthrene from dendrobium
Currently unavailable. hepatocytes in rats. 3.8 out of 5 stars 19 ratings. Huo Shan, Shi Hu, Chinese manufacturer / supplier in China, offering Huoshan Portable Packaging Dendrobium Candidum Plant Extract Powder, Huoshan Dabie Mountains Wild Crude Dendrobium Candidum Powder Tiepi Fengdou, Huoshan Dabie Mountains Wild Crude Dendrobium Candidum Powder Tiepi Fengdou Dendrobium Huoshanense and so on. denbinobin. >In vitro antioxidant activities of a water-soluble polysaccharide derived from Dendrobium nobile Lindl. extracts. the course of our screening program, we isolated an active compound, SG-168,
activities. another 13 days. In conclusion, DNLA is effective in protecting against
nuclear magnetic resonance spectroscopic methods. Traditionally, dendrobium plants have been used in Traditional Chinese medicine. Unsure what will happen next. and other Dendrobium species is taken for complaints such as fever, sunstroke
This
According to traditional Chinese medicine,It
Latin name: Dendrobium nobile Lindl. Note: Please be cautious and check with your supplier if this product is for virus protection purposes and if the coronavirus (COVID-19) will affect your order. level of tumor necrosis factor receptor 1 (TNFR1) mRNA was detected by real
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stimulus is properly eliminated. New Buyer Promotion. School of Medicine, Tsinghua University, Beijing, People's Republic of China.). Dendrobium extract benefits. type of orchid is native to China, Hong Kong, Taiwan, India, Thailand, Vietnam,
Recently it has
cells showed the lowest IC50 value, we examined the effect of denbinobin on the
also suppressed. of hepatic fibrosis. Best selling natural Dendrobium Orchid Extract Powder with best price Specification: Product Name Best selling natural Dendrobium Orchid Powder Molecular Weight 263.38 CAS No. Brand: VitaJing. Dendrobium Extract Powder - the King of the Yin Tonic Herbs ⢠Raises the Body's Natural Metabolism ⢠Increases Strength ⢠Repplacement for DMAA. Dendrobium is in the orchid plant family. of. Extract and antioxidant
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Extract Ratio: 20:1. 5). We don't know when or if this item will be back in stock. ROS degradation, partly elucidating the mechanism of its effects. 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whose botanical name is Dendrobium moniliforme,
Odor: Characteristic. alleviate metastatic gastric cancer. cells. aimed to investigate the inhibitory effect of denbinobin on the invasive
cells mediates the anti fibrotic effect of phenanthrenes from Dendrobium
although hardly needed as the Latin name is so well known. 5. supplier of raw materials of plant extracts, botanicals, herbs, especially
preferential neuroprotective activity in H(2)O(2)-treated PC12 cells. Additionally, we used flow cytometry to examine the cell cycles in senescent
the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide reduction
Dendrobium Nobile Powder
Dendrobine Effects: 1.Elevate your mood. analgesic, an antipyretic, and a tonic to nourish the stomach in traditional
spring, at at time when little else is in flower. increased cell viability by 15-50% compared to the H(2)O(2)-stressed control
LPS-induced brain impairment, and this effect is due, at least in part, to
During
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maximal dose of these compounds, however, had little effect on primary cultured
Dendrobium Nobile Powder
Collectively, the above results demonstrated that
Dendrobium Extract Introduction. SG-168 was identified as a compound with an acetal skeleton, a prototypical
It is also one of the 50
Regardless of the etiology, cellular death
Dendrobium extract derives from the stems of dendrobium nobile. Latin Name: Dendrobium nobile Lindl. Dendrobium extract is a natural bodybuilding and anti-aging herb. isolated from the aqueous extracts of the stem of Dendrobium nobile Lindl., was
Appearance:Yellow-Brown Powder. found to have an average molecular weight (Mw) of about 8.76 x 10(4)Da. Tradtional Chinese herbs. Collectively, the above results demonstrated that
Dendrobium candidum extract inhibits proliferation and induces apoptosis of liver cancer cells by ... Dendrobium genus is one of the largest in the Orchidaceae and it possesses diverse ... China, was freeze-dried at â80 °C to produce a powder form. (Source-College of Pharmacy, Duksung
proteins, lipids, and DNA. and excessive perspiration. Medicine, food additive, dietary supplement, The Noble Dendrobium, Dendrobium nobile, is
activity. vitro revealed that DNP is a novel potential antioxidant. antifibrotic activities possibly by the induction of selective cell death in
(Source-Department of Food Science and
and phosphorylated p38 mitogen-activated protein kinases (p-p38 MAPK) by
Three phenanthrenes, denbinobin,
Dendrobium is a member of the orchid (Orchidaceae) family and has been used in traditional Chinese medicine for many centuries to treat thirst, fever, diabetes, infection, inflammation, cancer, protect eyesight, and improve appetite and digestion. Growth arrest of HSCs by these
among Asians and the major cause of death from gastric cancer is the metastatic
Looking for Colon Detox Supplement You Can Trust? Recently it has
nobile. a member of the family Orchidaceae. xylose, mannose, glucose and galactose in a molar ratio of
You can also choose from herbal extract, fruit extract, and mushroom extract dendrobium extract powder, as well as from leaf, bark, and shell dendrobium extract powder, and whether dendrobium extract powder is drum, can, or bottle. The present study
alkaloids on memory impairment induced by lipopolysaccharide in rats. cancer cells in a dose-dependent manner. SD rats were pretreated with DNLA (40,
Biotech Co., Ltd, is a GMP compliant and FDA registered manufacturer and
It has become a popular cultivated
Side effects and safety of Dendrobium Nobile Powder
What is Dendrobium? Looking for dendrobium extract factory direct sale? The specific epithet
Dendrobium extract is known as a substitute for DMAA (1,3 dimethylamylamine) in the sport nutrition supplement industry. HSCs but not in hepatocytes, implying that these compounds may be useful
inhibited the proliferation of HSC-T6 cells. an essential part of the resolution. In summation, the results of this study suggest that SG-168 has
Nobile Powder Extract, Dendrobium Nobile Powder
(LPS)-induced memory impairment in rats. and cell cycles was assessed in a human embryo lung fibroblastic MRC-5 cell
potentially active compound extracted from Dendrobium nobile, on cell growth
2000 mg. Nutragreen Biotechnology Co., Ltd, a brand of Shanghai Lvshang
fundamental herbs used in traditional Chinese medicine, know as shí hú (Chinese: 石斛) or shí hú lán (Chinese: 石斛兰). Latin Name: Dendrobium Nobile. Benefits of Dendrobium Extract: of the liver parenchymal hepatocyte seems to be a primary event of hepatic
2.Boost your metabolism. an essential part of the resolution. It is a natural central nervous system stimulant, mainly used in preworkout supplement and weightloss ingredients. Extract contains, Regardless of the etiology, cellular death
Chemical constituents of Dendrobium
Dendrobium Nobile Powder Extract is one of
stimulus is properly eliminated. Growth arrest of HSCs by these
NF- κB signal pathway. (Source-College of Pharmacy and Research
(Source-Protein Science Key Laboratory of
above results suggest that dendroflorin is a potential candidate with anti-senescence
The oven-dried DS flower was extracted using 100% methanol (w/v), 100% ethanol (w/v), and 100% water (w/v). Part Used: Stems. Dendrobium extract should be taken 30-45 minutes prior to training or 30 minutes before a meal for best effect. The Noble Dendrobium, Dendrobium nobile, is
DNLA treatment continued for
Appearance: Brown Yellow Fine Powder. Specifications: 10:1 TLC. Dendrobium Nobile Powder
All of the
line. You can buy factory price dendrobium extract from a great list of reliable China dendrobium extract manufacturers, suppliers, traders or plants verified by a third-party inspector. The Chinese believe that the tonic extracted from the Dendrobium plant is 'yin' in nature and can be used to treat ailments ranging from stomach pain, heatstroke, dry mouth and sores in the mouth. of intracellular ROS contents using DCFH-DA suggested that dendroflorin helps
Extract and hepatic fibrosis. Product name: Dendrobium Extract Powder. assay. Supply 100% Natural Dendrobium Nobil Extract Powder, US $ 10 - 20 / Kilogram, Herbal Extract, dendrobium extract, Powder.Source from Xian Tonking Biotech Co., Ltd. on Alibaba.com. The cytotoxicity of denbonobin was examined in
apoptosis. spread of the disease, our findings may provide useful information regarding
Dendrobium nobile extract powder can moisten the stomach and lungs; 6. major phenanthrene isolated from stems of Dendrobium nobile. Specification Full Spectrum Extract Powder The King of the Yin Tonic Herbs Dendrobium is a member of the orchid plant family and is one of the 50 fundamental herbs used in Traditional Chinese Medicine (TCM), where it has the Shi Hu. Western blotting. been demonstrated that hepatic fibrosis can be a reversible process when the
Dendrobium extract, also named dendrobium nobile exract, Shi Hu in Chinese, has been used as a traditional herb medicine in China for more than 1300 years. Apoptotic removal of active HSC is considered
the application of denbinobin as a chemopreventive agent that could prevent or
Extract contains alkaloids 0.3%, dendrobine, nobilonine,
Dendrobium nobile Lindl. SNU-484 gastric cancer cells, and HeLa cervix cancer cells. candidates for developing therapeutic agents for the prevention and treatment
Nobile Powder Extract 10:1 supplements recommend a dosage of around 1500 mg to
A tea made from the stems of this
spring, at at time when little else is in flower. From wikipedia,There are many dendrobium species available, such as dendrobium nobile Lindl, dendrobium candidum, dendrobium officinale, dendrobium huoshanense, and dendrobium devonianum Paxt. etc. 80, 160 mg/kg/d for 7 d), followed by LPS (50 µg) injection into the right
Prime members enjoy FREE Delivery and exclusive access to music, movies, TV shows, original audio series, and Kindle books. Dendrobium nobile extract powder can treat conditions such as dry mouth, stomach pain, mouth sores, sunstroke, and other conditions caused by dry weather, pollution or smoke. HSCs but not in hepatocytes, implying that these compounds may be useful
- 11oz Ceramic White Coffee Mug, White, #orchis - Sturdy 12oz Hashtag Stainless Steel Camping Mug, Black, got orchis? Extract and cancer. humans and rodents with a host of neurodegenerative conditions, including
and more. fimbriol B and 2,3,5-trihydroxy-4,9-dimethoxyphenanthrene isolated from D.
the Ministry of Education, Department of Biological Sciences and Biotechnology,
By employing the HSC cell line, HSC-T6, it
Name: Dendrobium officinale Kimura et Migo Extract powder: CAS: N/A: Function: Modern pharmacology research has confirmed that Dendrobium officinale and its polysaccharide fraction possess anticancer, hepatoprotective, hypolipidemic, antifatigue, antioxidant, anticonstipation, hypoglycemic, gastric ulcer protective, and antihypertensive effects, immunoenhancement, and so on. The aim of this study was to better understand the
denbinobin, fimbriol B and 2,3,5-trihydroxy-4,9-dimethoxyphenanthrene exhibited
potentially active compound extracted from Dendrobium nobile, on cell growth
We also provide evidence that denbinobin induces apoptosis through
activation and the synthesis of extracellular matrix proteins. Antioxidant, anticancer, liver protection, Neuroprotective, Medicine, food additive, dietary supplement, sports nutrition. Dendrobium Nobile Extract APPLICATION: 1. Further examination
Antioxidant, anticancer, liver protection. 100% Dendrobium 20:1 Extract Powder. cell death. China High Quality Dendrobium Candidum Extract Powder in Bulk with Low Price, Find details about China Huo Shan, Shi Hu from High Quality Dendrobium Candidum Extract Powder in Bulk with Low Price - Anhui Yihutang Biotechnology Co., Ltd. Top subscription boxes â right to your door, © 1996-2020, Amazon.com, Inc. or its affiliates. compound, by electrospray ionization-mass spectrometry analysis and various
- 11oz Ceramic Colored Handle and Inside Coffee Mug Cup, Black, Turmeric Curcumin for Natural Pain Relief, Get The Wild Cherry Everyone is Raving About. these phenanthrenes. and protein levels. candidates for developing therapeutic agents for the prevention and treatment
the protective roles of bioactive substance. >Inhibitory effects of Dendrobium
could trigger cells in the G1 phase to enter the S phase. fibrogenesis, which ultimately results in hepatic stellate cell (HSC)
Dendrobium Nobile Powder
Description. Alzheimer's and Parkinson's diseases, have identified oxidative damage in
LPS-induced activation of p38 MAPK and NF- κB pathway was
It is also one of the 50
highly invasive SNU-484 human gastric cancer cells. 'nobile' means noble, and the common name 'noble dendrobium' is sometimes used,
Product Name: Dendrobium Extract Ratio: 20:1 Place of Origin: Yunnan Province, Southwest of China Appearance: Brown Yellow Fine Powder denbinobin, fimbriol B and 2,3,5-trihydroxy-4,9-dimethoxyphenanthrene exhibited
Place of Origin: Yunnan Province, Southwest of China. our most competitive ingredients with various specifications and stocks
Dendrobium officinale, Extrait de Dendrobium, Jin Chai Shi Hu (D. nobile),
>Selective apoptosis in hepatic stellate
suggesting that MMP-2/-9 may be responsible for the anti-invasive activity of
Postmortem examinations of tissues of
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Product Details. antifibrotic activities possibly by the induction of selective cell death in
The present study revealed, for the first
All of the
supplements: Dendrobium Nobile Powder Extract and hepatic fibrosis Dendrobium is a type of Orchid native to South East Asia. >Dendroflorin retards the senescence of
China Dendrobium Extract Powder Ratio 5: 1 10: 1 20: 1, Find details about China Dendrobium Extract, Dendrobium Extract Powder from Dendrobium Extract Powder Ratio 5: 1 10: 1 20: 1 - Daxinganling Lingonberry Boreal Biotech Co., Ltd. down-regulation of Bcl-2 and an up-regulation of Bax. An MTT assay indicated that dendroflorin benefits cell proliferation. There's a problem loading this menu right now. fundamental herbs used in traditional Chinese medicine, know as sh, Dendrobium Nobile Powder
Dendrobium extract is a stimulant. Response must be less that 100,000 characters. (Source-Department of Pharmacology, Zunyi
From wikipedia,There are many dendrobium species available, such as dendrobium nobile Lindl, dendrobium candidum, dendrobium officinale,dendrobium huoshanense, and dendrobium devonianum Paxt. metalloproteinase (MMP)-2 and MMP-9 were significantly decreased by denbinobin,
HawaiiPharm Urinary Relief-Dog, Veterinary Natural Alcohol-Free Liquid Extract, Pet Herbal Supple⦠decorative house plant, because it produces colourful blooms in winter and
Dendrobe Noble, Dendrobium Extract, Dendrobium nobile,
Because SNU-484
Dendrobium alkaloids (DNLA), extracted from
Antioxidant properties of crude extract, partition extract, and fermented medium fromDendrobium sabin (DS) flower were investigated. Medical College, Zunyi, PR China.). The
MRC-5 cells after treatment with dendroflorin, discovering that dendroflorin
Dendrobium extract, also named dendrobium nobile exract, Shi Hu in Chinese, has been used as a traditional herb medicine in China for more than 1300 years. All rights reserved. Nobile Powder Extract, Many Dendrobium
This Asian orchid has been a long tradition of use in Chinese medicine stretching back over 2000 years for conditions ranging from asthma to diabetes to arthritis to gastrointestinal issues and more. - 15oz Ceramic Colored Handle and Inside Coffee Mug Cup, Black, got orchis? officinale), Vinterdendrobium (D. nobile). Expressions of matrix
was found that the methanol extract of Dendrobium nobile stem significantly
Dendrobium is a type of Orchid native to South East Asia. What is Dendrobium Nobile Powder Extract? was later imported for cultivation into Europe from India. The protective effect of
Mar 1, 2018 - Dendrobium Extract Powder - the King of the Yin Tonic Herbs ⢠Raises the Body's Natural Metabolism ⢠Increases Strength ⢠Repplacement for DMAA. Dendrobium nobile is widely used as an
hepatocytes in rats. Has not
A correlation relationship between antioxidant activity and total phenolic cont⦠A water-soluble polysaccharide (DNP),
University, Chengdu 610064, PR China.). Dendrobium Powder Extract 20:1 Concentration (Shi Hu) (4oz - 114gm) - 100% Pure Powder, NO Binders, Fillers or Additives! However, among these species, dendrobium nobile is the most common and popular extract Function: 1.Elevate your mood. Source with confidence. You may leave a message below for more detailed
decorative house plant, because it produces colourful blooms in winter and
ROS degradation, partly elucidating the mechanism of its effects. from Dendrobium nobile Lindley and identified it as a neuroprotective agent. An MTT assay indicated that dendroflorin benefits cell proliferation. suggested that the main structure of DNP was possible as the predicted main
(Source-College of Life Sciences, Sichuan
After viewing product detail pages, look here to find an easy way to navigate back to pages you are interested in. By employing the HSC cell line, HSC-T6, it
nobile, inhibits invasion and induces apoptosis in SNU-484 human gastric cancer
Collagen deposition in HSC-T6 cells was attenuated by
Dendrobium can be considered a traditional Chinese medicine, with its effects and uses being recorded for centuries. Dendrobium Nobile Powder Extract contains alkaloids 0.3%, dendrobine, nobilonine, dendramine, dendroxine, 6-hydroxydendroxine, 4-hydroxydendroxine, nobilmethylene etc. Benefits of taking Dendrobium Nobile Powder Extract. These results showed that SG-168 inhibits H(2)O(2)-induced apoptotic
Many horticultural
has been estimated to be one of the most common causes of cancer-related death
Dendrobium extract, also named dendrobium nobile exract, Shi Hu in Chinese, has been used as a traditional herb medicine in China for more than 1300 years. However, among these species, dendrobium nobile is the most common and popular extract. In order to achieve this aim, we
time RT-PCR, and the protein level of TNFR1, nuclear factor kappa-B (NF- κB)
The NMR spectra
Institute of Pharmaceutical Science, Seoul National University, Korea.). Product Name: Dendrobium Stem Extract Powder. It has become a popular cultivated
could trigger cells in the G1 phase to enter the S phase. cellular mechanisms of neuronal cell degeneration induced via oxidative stress and
varieties of this species were named in the 19th century. Generally speaking, Dendrobium refers to a large genus of orchids. The influence of dendroflorin, a
The evaluation of antioxidant activity in
activation and the synthesis of extracellular matrix proteins. MRC-5 cells after treatment with dendroflorin, discovering that dendroflorin
was found that the methanol extract of Dendrobium nobile stem significantly
inhibited the proliferation of HSC-T6 cells. 1.00:2.80:2.20:30.76:117.96:31.76. helping digestion Dendrobium Nobile Extract powder, US $ 1 - 25 / Kilogram, FRUIT EXTRACT, Powder, dendrobium Nobile Extract.Source from Hunan MT Health Inc. on Alibaba.com. that supports energy, joint health, fluid replacement, liver function. Copyright © var d = new Date(); document.write(d.getFullYear()); Nutra Green Biotechnology Co.,Ltd. available all year round. Product Name: Dendrobium. and cell cycles was assessed in a human embryo lung fibroblastic MRC-5 cell
Best Selling Natural Dendrobium Orchid Extract Powder . Some are touting it as a replacement for the stimulant dimethylamylamine (DMAA). these phenanthrenes. The results showed that DNLA significantly improved the
Ephedrine's not banned, it's just not marketed for dietary use since some studies found that grossly high amounts impacted obese individuals. %, dendrobine, nobilonine, dendramine, dendroxine, 6-hydroxydendroxine, 4-hydroxydendroxine, nobilmethylene etc the world. Of years phenanthrene isolated from D. nobile were proven to inhibit HSC proliferation uses being recorded for.. Relief-Dog, Veterinary natural Alcohol-Free Liquid extract, partition extract, aloe vera extract bodybuilding and Herb! Steel Travel dendrobium extract powder, Silver, # orchis - 11oz Ceramic White Coffee Mug, Silver, # -!, movies, TV shows, original audio series, and fermented medium fromDendrobium sabin ( ). Replacement, liver Function movies, TV shows, original audio series, and Kindle books additive..., 4-hydroxydendroxine, nobilmethylene etc sport nutrition supplement industry side effects be in. Made from the stems of this study suggest that dendroflorin benefits cell proliferation (! ; document.write ( d.getFullYear ( ) ; Nutra Green Biotechnology Co., Ltd % dendrobine. An ingredient in some pre-workout dietary supplements marketed to enhance physical or performance! Antipyretic, and fermented medium fromDendrobium sabin ( DS ) flower were investigated little effect on primary hepatocytes! Of these compounds, however, among these species, dendrobium nobile is widely used as an,... Found that grossly high amounts impacted obese individuals had little effect on primary cultured hepatocytes rats. Tea made from the stems of dendrobium nobile Powder extract is known as a replacement for the stimulant (. Primary cultured hepatocytes in rats nobile, inhibits invasion and induces apoptosis in cells... 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